Oleander Products

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Dr. Robert Newman Experience and Education:
  • Professor Emeritus of Medicine and Pharmacology
  • University of Texas M. D. Anderson Cancer Center Co-Founder
    1984 – 2018 34 years
  • The University of Connecticut - MS and PhDPharmacology and Toxicology
    1970 – 1975
  • Activities and Societies: Alpha Phi Omega
  • Stanford University - Molecular Pharmacology and Immunology
    1984 – 1985
  • University of Vermont Pharmacology and Cell Biology |
    1976 – 1984
  • The University of Rhode Island Bachelor of Science (BS)Zoology and Chemistry
    1966 – 1970
  • University of Georgia Medical School PostGrad ResearchMolecular Pharmacology
    1975 – 1976

NAE-8 Patented by Phoenix Biotechnology and Oleander Products
Phoenix Biotechnology and the Science Behind Nerium Skin Care:
From historical/anecdotal use, continuing cancer and antiviral research with Nerium oleander extracts, Nerium Biotechnology, Inc. (NBI) has identified the potential for use of Nerium Ingredients in topical skincare applications. NBI’s proprietary technologies and product formulation provides for Nerium Ingredients to be the key ingredient in each product that will be designed and formulated for a specific target. This provides NBI with the opportunity to develop for the consumer an ever expanding series of natural botanical healthcare, topical, cosmetic and OTC skin products.

Dr Robert Newman Scientific Advisor for Phoenix Biotech: San Antonio, TX:
Phoenix Biotechnology’s Chief Science Officer, Chairman of the Scientific Advisory Board, and Director. Dr. Newman obtained his M.S. and Ph.D. degrees in Pharmacology and Toxicology from the University of Connecticut and then served in postdoctoral positions at the Medical School of the University of Georgia as well as the Department of Biochemistry at the University of Vermont. He served as a faculty member at the University of Vermont Medical School for seven years and then spent a sabbatical year at Stanford University performing research on immune targeted therapy. He spent 24 years at the University of Texas M. D. Anderson Cancer Center (MDACC) in Houston, Texas where he held the D. B. Lane Distinguished Professorship Chair. At MDACC he served as the founder and Co-Director of the Pharmaceutical Development Center and the institution's Analytical Center.

Dr Rick Matos: Phoenix Biotechnology’s Director. Dr. Matos has 32 years of experience as a pharmaceutical researcher, patent practitioner and consultant. He is an author of scientific articles and an inventor of pharmaceutical and chemical process technologies. He has integrated IP, business, R&D, regulatory, and commercialization strategies and built and managing robust large patent portfolios. Dr. Matos earned his doctorate in Bioorganic Chemistry from Texas A&M University after having completed his studies on the chemical and enzymatic synthesis of penicillin, amino acids and other natural products. He worked for The DuPont Merck Pharmaceutical Company as a Senior Research Scientist primarily on biotech large-scale process development and drug discovery in many therapeutic areas while advancing to Project Team Leader within the R&D department. After helping establish the pharmaceutical IP practice in the Dallas office of a major firm, Dr. Matos founded Innovar, L.L.C. in March of 2000.

Phoenix Biotech has developed a range of Nerium oleander extract (NOE) based products with different compositional profiles resulting from their respective methods of manufacture. Some of the products contain oleandrin and others do not.  In each case, however, the products contain components derived from plant.

The varying compositional profiles results in products exhibiting different biological activities.  Each of the products, however, is safe and effective when used as directed. This is because the products are effective even when administered at doses that are well below toxic doses. Please refer to our information on safety and therapeutic window.


Sponsor: Phoenix Biotechnology Inc. (Nerium)

Call Laurel Rose Clinical Research on NAE-8
Phoenix Biotechnology Oleander 4X

Scientists at Nerium Biotechnology, Inc. developed a breakthrough process, NBio-PL2 TM (plant- to-plant extraction), to derive the patented NAE-8 extract from Nerium oleander and Aloe barbadensis, while also preserving the unique ingredients and beneficial properties of both plants, without additional solvents. The exclusive NAE-8 extract has been shown in studies to contain antioxidant properties. This extract has changed the face of skincare and is one of the main key ingredients in the innovative Nerium Age Defying Night Cream.

Nerium Biotechnology, Inc., (NBI) is an international research and development company dedicated to science based product development. NBI, in concert with leading medical research institutions, has focused research and product development on the anti-cancer, anti-viral, immune-stimulating, and the dermal properties of natural botanical compounds. From this research, NBI has rediscovered, identified, and pursues the further development of well-defined constituents from the Nerium oleander plant. Utilizing proprietary technologies; NBI has been able to isolate and extract the core ingredients in a way that preserves the unique components and beneficial properties this plant has to offer. Thus allowing NBI to develop an ever expanding pipeline of “first of class” Nerium oleander-based products. Dr. Robert A. Newman, Ph.D., Professor Emeritus, Professor of Experimental Therapeutics, Founder and Co-Director of the Pharmaceutical Development Center at the University of Texas M.D. Anderson Cancer Center (MDACC) serves as lead researcher and scientific advisor to Nerium Biotechnology, Inc. His initial characterization and pharmacology research on Nerium oleander components provides the bases for product development and quality control. He continues to assist with continuing research and clinical trials.

For more information about Nerium Biotechnology visit:

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Oleander 4X from the Research of Phoenix Biotechnology
Historical use of the Nerium oleander plant and medicinal uses:
The oleander has a long history of cultivation amongst Mediterranean cultures. Some scholars believe the Rose of Jericho mentioned in Ecclesiastes is the oleander. Oleander is featured in paintings from some of the only surviving murals in Pompeii.

The plant was also revered by Greeks to honor their gods; the Moors for the sounds created by wind whipping its branches. Van Gogh’s painting, the cover illustration for this pamphlet, done in 1888, features oleander because he believed it had life-affirming flowers that bloomed exhaustively. This corresponds with the medical applications that Phoenix Biotechnology, Inc. (PBI) believes this plant provides.

Thomas Jefferson had a well-known interest in exotic flora, and friends around the world sent him many and varied plants, including oleanders, for his Monticello garden. He was so enchanted by the oleander and its flowers that he planted them throughout that famous garden.

Oleanders first arrived on this continent in bulk when a ship carrying them docked in 1841 at the important Texas port of Galveston. After the devastating 1900 hurricane which hit Galveston and took 9,000 lives, it earned the name “The Oleander City” because oleanders were the first plants to bloom after the hurricane. Today, Galveston is home to the most extensive collection of oleanders in the world. Certainly, the plant has established an identity for itself as hardy, prolific and beautiful.



Nerium Oleander and Phoenix Biotech

Oleander-4X is a homeopathic product that provides temporary relief from symptoms associated with colds, fever, aches, joint pain, immune support, may provide better sleep and more.

Oleander-4X is a whole leaf extract, which has been shown to be safe. Oleander-4X is 100% vegan, and does not contain high-fructose corn syrup, preservatives, artificial colors, flavors, or sweeteners.

The extracts used in Oleander-4X has been used safely in thousands of people over the last 18 months in the United States. Oleander-4X is an all-natural homeopathic drug that can easily be taken sublingually (under the tongue).

Oleander A Medicinal Tradition
Since humans first encountered the oleander, it has been seen as having extremely useful medical properties. Pliny the Elder, in volume XVI Chapter 79 of his book of natural history, mentions that oleander is toxic to animals, but for people it is an antidote against the poisons of snakes. Extracts
of the plant have been used as teas to settle upset stomach conditions and to treat ringworm, malaria,
leprosy, indigestion, venereal disease, fevers and heart failure. Bedouins used it to treat cancer and the Babylonians concocted a combination of licorice and oleander to relieve hangovers. It is still used around the world as an ingredient in folk remedies.

Despite, oleander’s tantalizing medical properties and ornamental beauty, it comes with a warning to those intending to exploit its medical benefits. The plant itself is toxic. It can produce vomiting, heart arrythmia, a skin rash and diarrhea. Rarely does it cause human death unless ingested in large quantities.

The answer to this problem, which was first addressed by the earliest practitioners, was to limit the amount of extract in the dosage to ensure the desired outcome for the user. Water or plant oil was used to dilute the plant extract to a suitable level for application either superficially or internally. The modern user of Nerium oleander benefits from vastly better systems of extraction and the science  to measure with precision the amount of Oleandrin – the active ingredient of the oleander plant -- in each application to ensure no harmful outcome to the patient.

We can now appreciate the oleander bush or tree as a unique TRIPARTITE PLANT.

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Nerium with NAE-8
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